Similarly, there was a significant correlation between the incidence of recurrence and increased EGFR RNA (p = 0.003) and a marginally significant correlation with EGFR protein overexpression ( p = 0.064) as well as between metastasis and p53 overexpression ( p < 0.0001), p53 mutation ( p = 0.04) and altered Rb expression ( p = 0.026).
Factors entered in the MVA were significant or of borderline significance in univariate analysis.
Statistical analysis revealed no significant relation between the expression level of the studied proteins except for the highly significant relation between p53 and EGFR overexpression where 20 out of the 21 (95.2%) p53 positive cases revealed EGFR overexpression while a single case only (4.8%) showed normal EGFR protein expression (p < 0.0001).