Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

Although Arg1 was hypothesized to be critical for collagen deposition [1] , [2] , the Arg1 −/flox ;LysMcre mice showed no impairment in hepatic fibrosis at the acute stage of infection, and surprisingly, displayed marked and highly significant increases in fibrosis when chronically infected ( Figure 2A ).

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