Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.

In fact, it was observed a highly significant (p < 0.0001) difference between the controls and MM or between MGUS and MM, while no significance was found between controls and MGUS groups (p = 0.95) by means of a two by two comparison of the three groups (controls, MGUS and MM) concerning the distribution of K- ras gene mutation, Interestingly, significant increases (P = 0.02) of serum bFGF levels were observed in patients showing K- ras gene mutation (median = 4.6 pg/ml; range = 1.2–19.6 pg/ml) as compared with those in which the gene was in the wild type form (median = 2.2 pg/ml; range = 1.0–20.8 pg/ml).

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