Abnormal functional specialization within medial prefrontal cortex in high-functioning autism: a multi-voxel similarity analysis.

In the control group there was a highly significant difference between the Same-Function and Cross-Function relationships [ t (15) = 5.4, P = 0.00008] whereas this comparison did not approach significance in the ASD group [ t (15) = 0.9, P = 0.4].

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However, in the ASD group, only one Same-Function relationship was significantly positive (Alphabet Attention versus Spatial Attention; t (15) = 2.5, P = 0.012, one-tailed), and in addition there was a positive Cross-Function relationship that just missed significance (Alphabet Attention versus Spatial Mentalizing; t (15) = 2.0, P = 0.06, two-tailed; Fig. 3 A).

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All other tests were non-significant [ t (15) < 0.9, P > 0.38], apart from a marginally significant negative relationship between the maps for Alphabet Attention and Spatial Mentalizing [ t (15) = 2.0, P = 0.07; there was no prior expectation of a relationship here, so a two-tailed test was used].

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