Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial.

Lancet · 2009 · PMC2668947 · PMID 19269519

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highly significantno p-value reported

The combined data from the CR07 trial and the Dutch trial (the two largest adjuvant radiotherapy trials, totalling 3211 patients) show a highly significant reduction in the rate of local recurrence with the use of preoperative radiotherapy (HR 0·38, 95% CI 0·29–0·49) when combined with total mesorectal excision ( figure 3 ).

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