In this study, we found a highly significant association between HLA and EHS using DNA-based high-resolution typing ( P positivity = 9.2×10 −11 ), suggesting an immunological pathogenesis for EHS.
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Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia).
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