Associations between the COMT Val/Met polymorphism, early life stress, and personality among healthy adults.

Neuropsychiatr Dis Treat · 2006 · PMC2671786 · PMID 19412467

Europe PMC DOI

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0.0800

closest p · 1.6× alpha

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a nonsignificant trendp = 0.08so close (0.05 < p ≤ 0.1)

Those individuals who were homozygous for the low-activity COMT enzyme allele ( Met/Met ) had lower scores on the extraversion personality dimension than those participants with the high-enzyme genotype ( Val/Val ) (F(1,253) = 5.10, p < 0.05); there was a nonsignificant trend for individuals with the low-activity genotype to have higher neuroticism (F(1,252) = 0.10, p = 0.08).

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