Beneficial effect of tibolone on mood, cognition, well-being, and sexuality in menopausal women.

In another randomised, double-blind, placebo-controlled study in healthy postmenopausal women, assessing QoL with the Nottingham Health Profile, tibolone-treated women showed a positive trend compared with placebo, especially for sleep and physical mobility.

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The Cognitive Abilities Screening Instrument (CASI) and Mini-Mental State Examination (MMSE) scores of the CEE+MPA group and of the tibolone group after 3 and 6 months of treatment showed an increasing trend in CASI and MMSE levels after treatment, although the increases were not statistically significant.

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