Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches.

Int J Mol Sci · 2009 · PMC2672036 · PMID 19399255

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an overall trendno p-value reported

An early study in the 1960s that showed an overall trend toward increased disease severity with plaque burden [ 23 ] has been refuted in a number of subsequent studies [ 24 – 26 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.