Use of clopidogrel in the reduction of myocardial damage during percutaneous coronary intervention.

In a subsequent analysis of these data, the CREDO investigators found that the benefit of clopidogrel loading became highly significant when administered at least 15 hours prior the procedure. 22 Thus CREDO expanded the indication for clopidogrel therapy to a more stable ischemic population group and also suggested the optimal clopidogrel therapy prior to PCI in terms of reduction of periprocedural thrombotic events was a loading dose of 300 mg given at least 6 hours and optimally 15 hours prior to PCI followed by a maintenance daily dose.

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