Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis.

A similar pattern was observed in the old female mice; the E max value was significantly lower in the group of mice that had received 0.05 mg/kg C 60 fullerenes (37.8% (95% CI: 32.6–43.0%)) compared to the control group (60.4% (95% CI: 53.2–67.6%)), whereas the E max value for the high dose exposed group was reduced (47.3% (95% CI: 38.6–56.0%)) although the difference was not quite statistically significant at a 5% level.

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