Ancient mtDNA genetic variants modulate mtDNA transcription and replication.

PLoS Genet · 2009 · PMC2673036 · PMID 19424428

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highly significantno p-value reported

While screening for human variants, we noticed a highly significant under-representation of variants within the highly conserved nucleotide positions (4/54), as compared to the evolutionary changed positions (16/46) (Fisher exact test, p = 0.0009).

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