Case-control approach to identify Plasmodium falciparum polymorphisms associated with severe malaria.

In the 5′ region of Rh2a/b there were alleles that had borderline significant univariate associations with severe malaria (in the intron and the microsatellite centred on codon 747), but these did not remain significant after adjustment for potential confounding by the logistic regression analysis ( Table 3 ).

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The 120 pairs of loci were ordered into four equal sized categories (n = 30) representing the quartiles of pairwise data (<4.5 kb, 4.5–29 kb, 29–68 kb, and >68 kb), revealing highly significant declines in significant LD throughout the distance range ( Figure 1D ).

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