Why Is Nodal Signalling Higher in Dorsal Positions? At 5 hpf, the expression of sqt and cyc is uniform throughout the margin of the zebrafish embryo [ 13 ], so what might cause the activation of Smad signalling to be higher in dorsal regions? Evidence suggests that the duration of signalling as well as the concentration of the morphogen may determine cell fate [ 17 , 33 , 34 ], and it may be significant that expression of sqt both commences on the dorsal side of the embryo and persists for longer in this region [ 13 ].
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Visualisation and quantification of morphogen gradient formation in the zebrafish.
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