Island method for estimating the statistical significance of profile-profile alignment scores.

BMC Bioinformatics · 2009 · PMC2678096 · PMID 19379500

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marginally significantno p-value reported

On the other hand, for marginally significant alignment scores between average length profiles, even a relatively small change in λ of 10% results in over 16 fold change in the estimated E-value (see Figure 2 ).

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