Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.

The results also agreed with previous findings [58] , [59] that the incubation temperature has highly significant effects on the viral polymerase activity (F = 271; P<0.001).

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By contrast, the origins of NP and PA were found to be insignificant and marginally significant (P<0.01; F<7), to the polymerase activity, respectively.

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