Transcriptional profiling of cattle infected with Trypanosoma congolense highlights gene expression signatures underlying trypanotolerance and trypanosusceptibility.

The expression of the GFM1 gene failed to increase significantly in PBMC from the Boran cattle over the time course; PBMC from N'Dama, on the other hand, displayed highly significant increases at 25 and 29 dpi in particular compared to pre-infection levels (1.7-fold, P = 0.0095 and 1.8-fold, P = 0.0085 respectively).

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Despite an almost significant 1.8-fold higher level of MAP4K3 mRNA in the Boran group relative to N'Dama before infection ( P = 0.0617); The N'Dama group had significantly higher expression levels of MAP4K3 at 25 dpi (1.5-fold, P = 0.0000) 29 dpi (1.6-fold, P = 0.0166) and 34 dpi (1.3-fold, P = 0.0058) relative to the Boran.

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