Evolution of mutational robustness in the yeast genome: a link to essential genes and meiotic recombination hotspots.

For rearrangement rates r <10 −4 , simulated architectures both with and without MAT loci preserved highly significant levels of essential gene clustering and anti-correlated meiotic crossover distributions over periods of at least 150,000 generations ( Figure 7A and 7B , Video S1 ).

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