Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration.

Although the interaction failed to reach significance at the middle hippocampal level, the ANOVAs for the individual cytokine infusion and chronicity main effects were significant, Fs (3,38) = 4.31, (1, 38) = 3.77, respectively, p < 0.05.

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