highly significantP = 1.1 × 10 −12
Results: A highly significant association with CD was observed, with the strongest signal at coding variant Arg381Gln (allele frequency, 2.5% in CD vs 6.2% in controls [ P = 1.1 × 10 −12 ]; odds ratio, 0.38; 95% confidence interval, 0.29–0.50).