highly significantP = 0.006
The increase was consistent across all three Hoxb regions tested (supplementary Table S2 ) and the difference in modification levels between the VPA-treated and untreated Hox genes was highly significant (H4K8ac, P = 0.006, H3K4me3, P = 0.0008; this and all subsequent comparisons use Student's two-tailed paired t test).