Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.

PLoS Comput Biol · 2009 · PMC2699117 · PMID 19578428

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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boldest claim

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highly significantp-value = 2.7e-5actually significant

Methods Ligand binding site similarity between COMT and InhA Previously, the SOIPPA algorithm had revealed a highly significant similarity (p-value = 2.7e-5) between the NAD binding site of the Rossmann fold and SAM binding site of the SAM methyltransferases [11] .

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