highly significantP < 0.01
The steady state of Egf expression and the significant upregulation of Tgfα and Egfr suggest the importance of this signaling pathways through Early Terminal Bud Stage (E16); however, beyond this point there is a highly significant (P < 0.01) decline in Egf , Tgfα , and Egfr expression, suggesting a greatly diminished role in SMG maturation.