For example, although none of the bantam sites are significant individually, their combined scores are highly significant and supported by experimental validation. 3′ UTRs with multiple predicted target sites are likely to be valid targets for regulation by the miRNA, particularly if their best single sites also rank high in the lists of predicted targets.
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The sentences
Clustering of top-scoring sites in a group of related genes is likely to be significant when it arises from an unbiased genome-wide analysis. miR-7 and miR-2 were selected for target validation. miR-7 Regulates Notch Targets Among the top 10 predictions for miR-7 , we found Enhancer of split ( E(spl) ) and Bearded ( Brd ) complex genes ( Figure 3 A).