Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis.

The difference in distribution of AKT-sensitive and AKT-insensitive drugs to the M area was statistically highly significant (Fisher exact test: p = 0.00011).As expected, the group of AKT-insensitive drugs mapping to the M region included typical microtubuli-targeting drugs such as colchicine, vinblastine, and podophyllotoxin.

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