REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

However, after PTPN22 the second most significant association is observed on chromosome 2 in the region of REL , where two markers provide highly significant evidence of association (rs13031237, allele specific p=6.01 × 10 -10 and rs13017599, allele specific p=9.05 × 10 -9 ), as shown in Table 1 .

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