Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum.

PLoS Pathog · 2009 · PMC2705182 · PMID 19609357

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highly significantno p-value reported

The observation that α-toxin induces the release of HMGB1 from muscle cells is a highly significant finding, considering its immunostimulatory properties.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.