A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

Hum Mol Genet · 2009 · PMC2706684 · PMID 19429911

Europe PMC DOI

hedged sentence

0.0000

closest p · 0.0× alpha

0.0000

boldest claim

The sentences

highly significantP < 10 −8actually significant

Two additional studies have demonstrated highly significant associations between rs1051730 and lung cancer (OR ≈ 1.3; P < 10 −8 ) but found either weak or no evidence of association with smoking behaviour, suggesting that further work is necessary to determine whether the variant has a role in disease susceptibility independently of smoking behaviour ( 15 , 16 ).

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