A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability.

Specifically, we calculated the significance of (i) the number of genes within 250 bp of both the ChIP-chip hits and binding motif sequences (one extra bp in motif degeneracy was allowed for a few of the genes in Figure 4A, which were nearby ChIP-chip hits, which showed a highly significant change in the microarray data; Figure 4A ); (ii) the number of genes whose expression changed in the trmB mutant, which were also within 250 bp of a ChIP-chip hit; (iii) the number of genes changing in the transcriptome data, which contained a motif within 250 bp of their transcription start site ( Figure 4B ).

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