Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners.

BMC Chem Biol · 2009 · PMC2711050 · PMID 19523227

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highly significantno p-value reported

However, a similar analysis of the directlyinteracting partners of 28 common targets of multiple reactive metabolites revealed highly significant enrichments in terms likely to be highly relevant to cytotoxicity (e.g., MAP kinase pathways, apoptosis, response to unfolded protein).

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