highly significantp < 0.0005
The results of two non-RCTs were additionally combined in an individual patient data meta-analysis, and showed highly significant results (HR: 0.43, 95% CI: 0.34–0.56, p < 0.0005) [ 135 ].
The results of two non-RCTs were additionally combined in an individual patient data meta-analysis, and showed highly significant results (HR: 0.43, 95% CI: 0.34–0.56, p < 0.0005) [ 135 ].
The results of the latter two RCTs were also combined in an individual patient data meta-analysis; the result just missed significance (HR: 0.59, 95% CI: 0.34–1.02, p = 0.057) [ 135 ].
Concerning survival (Table 3 ), some of the RCTs show a statistically significant benefit while others show a statistical trend or no difference.