Linking white and grey matter in schizophrenia: oligodendrocyte and neuron pathology in the prefrontal cortex.

Association analysis of PTPRZ1 showed highly significant association of this gene to schizophrenia in this first study, however, this association was not replicated in a Japanese cohort (Ito et al., 2008 ).

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The fact that the PFC matures last and that myelination is not complete until late adolescence may be significant, as the timing coincides with the typical onset of symptoms in schizophrenia.

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