Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration.

In degenerative cartilage diseases such as osteoarthritis, degradation of the proteoglycans has been shown to precede breakdown of the collagenous molecules [ 23 ], so a greater initial upregulation of stromelysins may be significant in this regard.

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