Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.

For major coronary events in the primary prevention trials, the 11 separate tests for trend or heterogeneity of effect yielded only one, between men and women, that was marginally significant (p=0·03; figure 3 and webappendix p 4 ) if considered in isolation, but it was no longer significant if multiplied by 11 to allow for multiple comparisons (p=0·33).

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