Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection.

However, ongoing recruitment of antigen-specific CD8 + T cells from a munificent naive pool may continue to sustain a more effective response throughout the course of infection ( 53 ); in this regard, the correlation between clonotypic diversity and the number of public clonotypes is notable despite the fact that the latter parameter in isolation did not achieve significance with respect to measures of disease progression in the present study.

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