marginal significanceP = 0.067
A randomized controlled trial in 96 patients showed that lymphoblastoid IFN 5 MU in combination with thymosin α-1 1.6 mg 3 times weekly for 24 weeks increased HBeAg loss 1 year after the end of treatment with marginal significance in comparison with IFN monotherapy (45.8% vs. 28%; P = 0.067) [ 57 ].