Gene expression analysis of an EGFR indirectly related pathway identified PTEN and MMP9 as reliable diagnostic markers for human glial tumor specimens.

To further elucidated if PTEN and MMP9 expression had an expression trend that reflected the malignant grade of the specimens (i.e., normal, anaplastic astrocytomas, and glioblastoma multiforme), a statistical trend analysis was performed ( Figure 6 ); the analysis reported in Panel A showed that PTEN and MMP9 differences in their normalized expression clearly decreased following the malignant glioma grading, with the lowest values corresponding to glioblastoma multiforme specimens; similarly, the trend analys

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