Indeed, and independent of the polymorphisms of TP53 , one can notice a highly significant difference between cell lines with wild-type and mutated p53: cell lines having a p53 mutation had a significantly lower sensitivity to most drugs than cell lines having no p53 mutation.
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The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models.
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