Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention.

The 39,X Y *O mice, which lack steroid sulfatase expression throughout development, demonstrated impaired 5-CSRTT performance (significantly increased omissions and a nonsignificant trend toward impaired accuracy at short stimulus durations) relative to 40,XY control mice; these deficits were rescued in the 1-CSRTT.

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