Identification of pediatric septic shock subclasses based on genome-wide expression profiling.

All signal intensity-based data were used after RMA normalization, which specifically suppresses all but significant variation among lower intensity probe sets [ 17 ].

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While this result suggests that the three putative septic shock classes have highly significant differences in gene expression, a working gene list of more than 20,000 genes is excessively large for practical analysis.

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