The levonorgestrel-releasing intrauterine system: Safety, efficacy, and patient acceptability.

14 Another study of 92 women with the LNG-IUS inserted for menorrhagia showed a marginally significant reduction in total cholesterol from baseline, a reduction in HDL at 6 months which reverted to baseline by one year, while triglycerides, LDL, apolipoprotien A1 and apolipoprotein B remained stable over the course of 18 months. 15 Therefore, though the WHO recommendations warn of a theoretical effect of the LNG-IUS on lipid levels and caution its use in women with multiple cardiac risk factors, studies do not show this to be a significant problem associated with the LNG-IUS.

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