Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.

Biochem Biophys Res Commun · 2009 · PMC2726921 · PMID 19523444

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highly significantno p-value reported

However we did find a highly significant decrease in the tau-phosphatase PP2A in Irs2 −/− mice, suggesting that the mechanism of effect might be mediated not by an increase in kinase activity but by a decrease in the activity of this phosphatase.

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