The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

Haplotype analysis identifies a highly significant risk haplotype specifically associated with classic PTC cases Five out of six significant SNPs in FOXE1 were located in a single LD block ( Figure 1 ), and were subsequently used for haplotype analysis of the region spanning from chromosomal coordinates 99,648,503 to 99,668,059 ( Figure 1 , Table 2 ).

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