Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial.

In participants randomized to nebivolol, those with moderate renal impairment or worse had a comparable safety profile to participants with normal or mild renal impairment, apart from a marginally significant increase in bradycardia [10 out of 440 patients (2.3%) vs. 5 out of 620 patients (0.8%); P = 0.046].

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