Using parents with three or more offspring (119 AGRE mothers, 119 AGRE fathers, 374 FHS mothers, and 356 FHS fathers), we conducted an analysis of variance to compare the variability of recombination in different meiotic events (offspring) within an individual to the variability between individuals, and found highly significant individual differences in mean recombination frequency among men (P AGRE = 5.14×10 −12 , P FHS = 2.83×10 −49 ) and women (P AGRE = 1.09×10 −16 , P FHS = 8.97×10 −18 ) in both samples.
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