Genome-wide analysis of small RNA and novel MicroRNA discovery in human acute lymphoblastic leukemia based on extensive sequencing approach.

Interestingly, another cluster of highly significant GO terms was associated with nervous system development, i.e. neuronal cell differentiation, which might be associated with the pathogenesis of ALL with subsequent central nervous system (CNS) relapse, suggesting that a set of significantly dysregulated miRNAs might promote the progression of CNS relapse in ALL by regulating genes in the pathway of nervous system development.

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