ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan.

Diabetes · 2009 · PMC2731525 · PMID 19502413

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highly significantno p-value reported

In contrast, we showed a highly significant negative correlation between the apoCIII/apoB molar ratio and the content of unesterified cholesterol, sphingomyelin, ceramide, and the ceramide-containing ganglioside GM1 in LDL isolated from subjects with type 2 diabetes but not in LDL isolated from control subjects ( Fig. 2 C–J ).

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