did not achieve significanceP =0.09
The Cox regression curve for MVD and proliferating ECs ( Figure 4 ) showed a decreased survival in invasive breast cancer patients exhibiting a high CCS (greater than the median (59 for MVD and 22 for proliferating ECs)) when compared with patients with a low CCS (equal to or less than median for both parameters), which did not achieve significance ( P =0.09 and P =0.12, respectively), probably because of the relatively small numbers of patients in the study.