A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.

J Exp Med · 2009 · PMC2737161 · PMID 19652017

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closest p · 0.0× alpha

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highly significantP < 0.001actually significant

One group demonstrated a highly significant (>200-fold; P < 0.001) induction of anti-ClfA IgG2a titers when mice were vaccinated with ClfA and c-di-GMP as compared with vaccination with ClfA alone ( Karaolis et al., 2007a ).

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