Balancing selection of a frame-shift mutation in the MRC2 gene accounts for the outbreak of the Crooked Tail Syndrome in Belgian Blue Cattle.

Highly significant reductions in MRC2 mRNA levels were observed in carriers relative to homozygous wild-type individuals (75%±4% and 45%±6% of control values for the 5′ and 3′ systems respectively), while MRC2 mRNA levels in cases were less than 5% of homozygous wild-types ( Figure 3B ).

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